Motorway A1, exit at Chiusi-Chianciano Terme on the road Firenze-Roma. Then follow the indication towards Chianciano Terme and Monte Amiata until SS Cassia and  towards Bagni San Filippo.

Airport Leonardo Da Vinci – Roma Fiumicino
Airport A.Vespucci, Florence

Airport G. Galilei, Pisa
Airport Roma Ciampino

Station of Chiusi-Chianciano Terme. From here bus to Santa Fiora or taxi.