From Milan: motorway Milano-Bologna-Firenze, exit at Chiusi-Chianciano Terme, follow the indication towards San Casciano dei Bagni

From Rome: motorway A1 direction north, then exit at Fabro follow the indication towards San Casciano dei Bagni

Airport A.Vespucci, Florence (150 km)
Airport Leonardo Da Vinci – Roma Fiumicino (200 km)

Airport Roma Ciampino